Interprofessional collaboration strategies and interventions are carried out to improve patient safety in hospitals. This study aimed to analyze the strategies and interventions used in interprofessional collaboration to improve patient safety. Interprofessional collaboration strategies and interventions were searched using five English-language databases, eligible studies were extracted, and the risk of bias was independently evaluated by two authors. The literature search yielded a total of 10,729 registered papers. We conducted an analysis on 3,793 health professionals. The following articles were included: 1) articles that described an intervention interprofessional collaboration to improve patient safety; 2) those focused on interprofessional collaboration in hospitals; and 3) the research sample included of health care professionals (doctors, nurses, nutritionists, and pharmacists). Interventions that combine lectures, skills practice, and discussions are carried out using an online format and case study practice. The strategies and interventions identified inductively were categorized into four items: 1) team acceptance and readiness for interprofessional collaboration; 2) acting as a team and not as individuals; 3) developing protocols or guidelines for health professionals; and 4) integrating elements of interprofessional collaboration by health professionals in providing health services. The principles of interprofessional collaboration include the need to prioritize structures, processes, and tools that enable interprofessional collaboration to be established in hospitals. Interprofessional collaboration strategies and interventions in hospitals are effective in being able to make changes to improve patient safety and the quality of service. © JKI 2025.