Survival of Salivary Gland Cancer and Its Associated Clinicopathological Factors: A Retrospective Cohort Study at a National Referral Hospital in Indonesia
Informasi
JurnalJournal of Head and Neck Physicians and Surgeons
PenerbitWolters Kluwer Medknow Publications
Volume & EdisiVol. 13,Edisi 2
Halaman185 - 191
Tahun Publikasi2025
ISSN23478128
Jenis SumberScopus
Abstrak
Context: Salivary gland cancer (SGC) is a rare and heterogeneous malignancy characterized by diverse clinicopathological features. In Indonesia, limited data exist regarding survival outcomes and associated prognostic factors. Aims: The aim of this study was to determine the 3-year overall survival (OS) rate of SGC patients and to evaluate the association between clinicopathological factors and survival outcomes. Settings and Design: A retrospective cohort study was conducted at Cipto Mangunkusumo General Hospital, a national referral hospital in Indonesia. Materials and Methods: Data from 32 SGC patients registered between 2019 and 2021 were analyzed. Clinicopathological and survival data were collected from medical records and supplemented with telephone interviews. Statistical Analysis: Survival was estimated using the Kaplan-Meier method. The association between variables and survival was analyzed using Cox proportional hazards regression. Results: The 3-year OS rate for SGC patients was 67.9%. The most frequent histologies were adenoid cystic carcinoma and mucoepidermoid carcinoma (31.3% each), with a majority of patients (78.1%) presenting at an advanced stage. No clinicopathological factors were found to be statistically significant predictors of survival. However, lymphovascular invasion (LVI) showed a trend toward being a negative prognostic factor (hazard ratios = 3.24; P = 0.201). Conclusions: The 3-year OS for SGC patients in this cohort was 67.9%. While no factors reached statistical significance, LVI may be an important prognostic marker. Larger, multicenter studies are needed to confirm these findings. © 2025 Journal of Head & Neck Physicians and Surgeons.
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