We report three pediatric patients with alopecia areata and high seropositive immunoglobulin G of rubella, toxoplasmosis, cytomegalovirus, and herpes simplex virus. We treated the patients with a combination of topical and intralesional injections of corticosteroids, topical minoxidil 5%, inosine pranobex, valacyclovir, and light-emitting diode therapy with excellent results. © 2023 Pakistan Association of Dermatologists. All rights reserved.