This study aimed to determine the factors influencing the community’s acceptance of booster vaccination, focusing on sociodemographic characteristics, knowledge, media exposure, and attitude. An analytical observational design was used with a quantitative method and cross-sectional study. The data were collected in September and October 2023 through a digital questionnaire using the Google Forms platform distributed by Line, WhatsApp, Instagram, Twitter, and TikTok, and 425 respondents from Indonesia were selected. Data analysis included univariate, bivariate (Chi-Square Test), and multivariate analyses (Multiple Logistic Regression Test) using IBM SPSS Statistics. The results showed that the majority of respondents possessed good knowledge (51.8%), were actively exposed to the media (99%), and showed a positive attitude toward booster vaccination (57.9%). Furthermore, this study showed that gender, education, knowledge, and attitude had a statistically significant relationship with the community acceptance of booster vaccination and education was found to be the most influential variable in the community acceptance of booster vaccination. The education levels and knowledge were found to have a significant relationship with the attitude and actions of the community. To face the threat of a future pandemic, the government can focus on equal distribution of education and dissemination of information related to disease (prevention, symptoms, treatment, and more) while also building public trust in the government and health workers. This study aims to see the overview of public knowledge, attitudes, and behavior towards booster vaccines in Indonesia. The factors that influence people to do or not do booster vaccines are very diverse. Therefore, the results of this research can be used for future learning when a pandemic is possible. This research was conducted using online questionnaires and shared through social media. The respondents in this study are Indonesian citizens who are adults or over 18 years old the results of this research indicate that education is the dominant factor influencing people to get a booster vaccine Therefore, education should be maximized to enhance booster vaccination in case of future pandemics © The Author(s) 2025. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).