Topical gels are often prescribed to alleviate distressing pain caused by wounds in the oral cavity. Several active compounds may be loaded into gels aimed to address the pain caused by the wound while simultaneously improve wound healing in the oral cavity. This systematic review aimed to assess clinical evidence of topical gels on wound healing in the oral cavity. A systematic review were conducted following and reported following the PRISMA 2020 guidelines. A number of 1,961 literature from 3 databases were screened following the predetermined inclusion and exclusion criteria. 11 articles were included in this systematic review assessing acute wound healing and clinical parameters of several topical gels in the oral cavity. The studies recorded clinical studies assessing 6 active compounds of topical gels on acute wound healing in the oral cavity. Various doses were reported in the included studies administered either professionally or self-applied. The reported parameters were clinical assessment of wound healing, pain, and gene expression, suggesting some evidence of better wound healing in the test group of gels containing hyaluronic acid, simvastatin/chitosan, phenytoin, erythropoietin, tryglicerol oxide, and essential oil-based gels. Topical gels are convenient delivery system with favorable outcomes on clinical wound healing. © (2024), (University of Dicle). All rights reserved.