Maintaining stable pressure in the oxidation–compressor section of purified terephthalic acid (PTA) plants is essential for ensuring efficient and reliable operation. Conventional single-loop proportional integral derivative (PID) controllers frequently perform inadequately because of the large pressure drop between the compressor discharge and reactor inlet, which should ideally remain at approximately 1.2 kg/cm2 above the reactor pressure setpoint but can reach up to 2.8 kg/cm2 due to downstream vapor-phase disturbances. Through this study, we aimed to address this issue by developing a robust cascade pressure control strategy to improve pressure stability and reduce energy losses. Dynamic process models were constructed using system identification techniques to represent real plant behavior, and the best-performing models—identified based on minimum root mean square error (RMSE)—were determined using the Wade method for pressure indicating controller PIC-101, the Lilja method for PIC-102, and the Smith method for pressure differential indicating controller PDIC-101. The proposed cascade configuration was tuned using the Lopez ISE method and evaluated under representative disturbance scenarios. The results showed that the cascade controller significantly improved pressure control, enhanced disturbance rejection, and lowered the risk of reactor shutdowns compared with the conventional proportional-integral PI-based approach. Overall, this study demonstrated that model-driven cascade control can enhance robustness, operational reliability, and energy efficiency in large-scale PTA oxidation processes. © 2026 by the authors.