Ambient air pollution, especially from fine particles, contributes to human mortality from cardiovascular and respiratory diseases, for which high blood pressure (BP) is a major modifiable risk factor. This study aimed to analyze the influence of ambient particulate matter (PM2. 5) on the risk of high BP leading to hypertension. This study used a cross-sectional design on 118 adult women living in Central Jakarta, Indonesia. Participants were selected from a 1-km radius of the nearest air quality monitoring station with available data PM2. 5. Linear regression was analyzed to examine the relationship between PM2. 5 and systolic and diastolic BPs adjusted for potential confounders. The annual means of PM2. 5 concentration was 36±5.74 μg/m3. The linear regression model showed that PM2. 5 exposure was associated with systolic BP after controlling with age and body mass index (r= 0.408; R2= 0.167). The second model showed that exposure to PM2. 5 concentration could explain about 10.9% variation of diastolic BP after controlling with age, length of stay, body mass index, smoking status, and diabetes mellitus record. Ambient air PM2. 5 has a risk of BP and hypertension among adult women in Central Jakarta.