Introduction: Uncorrected refractive errors are a leading cause of preventable vision impairment globally, particularly affecting individuals in low-resource regions where timely diagnosis and screening access remain significant challenges despite the availability of economical treatments. Aim: This study introduces a novel deep learning-based system for automated refractive error classification using photorefractive images acquired via a standard smartphone camera. Methods: A multi-branch convolutional neural network (CNN) was developed and trained on a dataset of 2,139 corneal images collected from an Indonesian public eye hospital. The model was designed to classify refractive errors into four categories: significant myopia, significant hypermetropia, insignificant refractive error, and not applicable to classified. Grad-CAM visualization was employed to provide insights into the model’s interpretability. Results: The 3-branch CNN architecture demonstrated superior performance, achieving an overall test accuracy of 91%, precision of 96%, and recall of 98%, with an area under the curve (AUC) score of 0.9896. Its multi-scale feature extraction pathways were pivotal in effectively addressing overlapping red reflex patterns and subtle variations between classes. Conclusion: This study establishes the feasibility of smartphone-based photorefractive assessment integrated with artificial intelligence for scalable and cost-effective vision screening. By training the CNN model with a real-world dataset representative of Southeast Asian populations, this system offers a reliable solution for early refractive error detection with significant implications for improving accessibility to eye care services in resource-limited settings. Copyright © 2025 Syauqie, Patria, Hastono, Siregar, and Moeloek.