Treatment of deep carious lesions is typically accomplished by complete caries removal, risking pulp necrosis. With dental science and technology advancements, dentists can currently perform minimally invasive caries removal by leaving a partial carious lesion. We evaluated the remineralization of affected dentin after leaving partially infected dentin (Group 1) or removing all infected (Group 2) dentin. BiodentineTM was applied to the participants in both study groups and they were evaluated after four weeks. (Ethical Clearance No: 100/EthicalApproval/FKGUI/XII/2016). Both groups showed radiographically insignificant remineralization from baseline to week four. Between-group comparisons of remineralization were also insignificant. Affected dentin remineralization can occur whether the infected dentin is left partially intact or is completely removed. © 2019, Journal of International Dental and Medical Research.