Jakarta is the capital of Indonesia, the problem of waste cannot be adequately handled by the authorities, and there is still space for improvements to be done. Rapid of globalization and industrial development 4.0. The increase of mass waste production in Jakarta, lacking awareness of the community to dispose of waste in its place coupled with household waste generated by the community and small and medium-sized industrial businesses. This study aims to Responsible Waste Management of Micro, Small, and Medium Enterprises (MSMEs) Toward Jakarta Sustainable Development, in overcoming the waste problem, and it is necessary to have the cooperation of the authority. The community and small and medium industrial entrepreneurs need to be given training and counseling on waste management which can later be reused by small and medium industrial entrepreneurs. The finding of this study is a significant reference to the sustainable development initiative towards a clean and waste-free Jakarta living environment. © Springer Nature Singapore Pte Ltd. 2021