The treatment given to children who have been confirmed positive for COVID-19 and are showing symptoms involves iso-lation, which consequently is an unpleasant experience for pediatric patients. In isolation rooms, children reported a “roller-coaster” of feelings due to being separated from their families and familiar surroundings. This study examines children’s emotions while being hospitalized in isolation rooms due to COVID-19. The study follows a descriptive qualitative design. Online inter-views were carried out and involved 10 children who had been confirmed positive for COVID-19 and were hospitalized in two big cities in Sumatra. Four themes emerged from the data: i) chil-dren’s emotional conditions after finding out they had positive COVID-19 test results; ii) boredom and inconvenience during isolation; iii) support from the children’s peer; and iv) happy responses to receiving negative swab results and being allowed to go home. These themes describe the children’s adaptation process to isolation based on the feelings they expressed during the inter-views. This study suggests that, in order to improve their facili-ties, hospitals should support children’s activities during isolation and nurses should improve their therapeutic communication with pediatric patients. © the Author(s), 2023.