The quality of life (QOL) of post-stroke patients can be assessed from the reports of patients themselves obtained through a structured interview or a questionnaire. However, some individuals are unable to comprehensively describe their QOL because of language disorders, cognitive effects caused by stroke, or pre-existing conditions. This study aims to identify differences in post-stroke QOL perception between patients and caregivers. A cross-sectional design involving 115 stroke patients and 115 caregivers was adopted, and Mann–Whitney test was used for statistical analysis. Results showed no significant difference in QOL perception (p = 0.166; α < 0.05), particularly in the physical (p = 0.278; α < 0.05), psychological (p = 0.068; α < 0.05), social relationship (p = 0.976; α < 0.05), and environmental (p = 0.157; α < 0.05) domains between patients and caregivers. Therefore, information from caregivers can be used to assess QOL when patients are incapable of reporting their condition. © JKI 2021.