As a place to store goods, a warehouse needs to hold a heavy load (12-25 kPa) and requires a large space so that the building structure has a long span between columns (11-17 m) and a large height between floors (5-11 m) but also complies with the code to produce a seismic resilient infrastructure. However, building structures in Indonesia generally are designed using Special Moment Resisting Frame (SMRF) with the slabs generally supported by beams that tend to only be able to withstand small loads (2-6 kPa) and is only suitable for spans of 6-9 m. Previous studies have shown that Post-Tensioned Flat Slab (PTFS) structure with the application of Separated Gravity and Lateral load Resisting (SGLR) systems is a promising solution for this problem. This study aims to determine the effective strand distribution layout and compare the SMRF structure with PTFS structure in terms of seismic responses and cost based on material volume. A case study of a warehouse building with 11.4 m span, 25 kN/m2 live load, and 11.2 m height between floors is used. For the PTFS structure, three types of strand distribution layouts will be studied. The analysis was carried out using the assistance of ETABS 21 with response spectrum seismic load. The analysis results showed that the distribution of the strand did not produce a significant difference in terms of slab stress and the PTFS structure with the application of SGLR produces a safe seismic response and is more cost-effective compared to the SMRF structure, making it feasible for use in warehouse buildings in earthquake-prone areas of Indonesia. © 2025 Institute of Physics Publishing. All rights reserved.