Background: Self-management is a cornerstone of effective type 2 diabetes mellitus (T2DM) care, yet many patients face challenges due to low health literacy, poor self-efficacy, and lack of psychosocial support. Several intervention models have emerged to address these barriers, including educational programs, digital platforms, family-based support, and community engagement strategies. Objectives: This study evaluates the effectiveness of a module with multidimensional self-management interventions to improve clinical and behavioral outcomes in patients with T2DM. Methods: This review identifies 13 studies from 2016-2025, using designs like RCTs, quasi-experimental, and participatory research. They were examined thematically to evaluate their influence on diabetes selfmanagement, clinical outcomes, and patient empowerment. Results: The findings revealed that interventions targeting health literacy, peer support, and digital education platforms resulted in statistically significant self-care behaviors and psychological outcomes. Family involvement and nurse-led initiatives improved the long-term success and effectiveness of the intervention. However, low-intensity or entertainment-based strategies showed limited impact on knowledge acquisition. Digital tools demonstrated potential, but their success depended on user engagement and context relevance. Conclusion: Multidimensional, culturally sensitive interventions integrating education, emotional support, and social structures substantially improve diabetes self-management outcomes. The hypothesis that such interventions are effective was supported. Future studies should evaluate long-term sustainability, cost-effectiveness, and scalability across healthcare systems. © 2026, Asia Pacific Higher Learning Sdn Bhd., Lincoln University College. All rights reserved.