Diabetic foot ulcer infection (DFUI) is a frequent complication among diabetic patients, with the highest mortality rate worldwide. This study aims to identify factors that affect mortality in DFUI patients. The cross-sectional study was conducted at Cipto Mangunkusumo Hospital (RSCM), Jakarta, Indonesia. Medical records of 259 DFUI inpatients were collected from January 2019 to December 2022. The patient outcome observed was mortality. Most of the DFUI patients were women (52.1%), with Type 2 Diabetes Mellitus (T2DM) (98.5%), with a mean age of 59.65 ± 10.83 years and a duration of DM of 9.03 ± 7.29 years. The mean BMI was 24.85 ± 4.95 kg/m2, with 38.6% of patients smoking. Comorbidities included hypertension (51.4%), peripheral artery disease (51.4%), dyslipidemia (34.7%), and CAD (14.3%). The majority (64.1%) had severe infection. Severe infection and CAD both elevated mortality risk by 5.202 times (95% CI, 1.397–19.375) (p = 0.014) and 5.578 times (95% CI, 2.037–15.272) (p = <0.001) compared to those without severe infection or CAD. Dyslipidemia elevated mortality risk by 2.309 times (95% CI, 0.881–6.057) (p = 0.089). This study showed factors that affect mortality in DFUI patients are severity of infection, CAD, and dyslipidemia, which is in accordance with various studies conducted worldwide. © 2025 Fitrianingsih et al.