Background: Appropriateness of code trauma activation is one of the important factors for successfully managing polytrauma patients. However, no sensitive and specific indicator is available to activate code trauma. The study aims to develop and examine the diagnostic value of Skrining Politrauma Universitas Indonesia – Cipto Mangunkusumo (SPIC). Method: A mixed-method sequential exploratory design was used. This study consisted of two steps. The first step aims to develop SPIC using four methods: literature review, qualitative exploration, expert consultation, and predictive logistic regression. The second step aims to examine the diagnostic value of SPIC using a quantitative approach. Results: The SPIC was developed based on seven indicators, including the level of consciousness, airway, breathing, circulation, injury mechanism, injury location, and organ involved. The diagnostic test results showed that SPIC is a good instrument for screening polytrauma patients in Triage, with a sensitivity of 91%. Conclusions: SPIC is a sensitive instrument to screen polytrauma patients in Triage. SPIC can be used to activate the code trauma team. © 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.