Background: The number of papillary thyroid carcinoma is increasing worldwide compared to the other histopathologic types. There are several aggressive subtypes of Papillary thyroid carcinoma (PTC), where tall cell variant (TCV) is being one of them. TCV-PTC also has oncocytic cytoplasm histologically. We aim to characterize the clinicopathological features and to assess treatment results of tall cell variant papillary thyroid cancer. Material and methods: This is a retrospective analytical study. Clinicopathological characteristics, such as characteristics of the tumor, including tumor size, stage, pathological lymph node, metastasis, lymphovascular invasion, multifocality, peri thyroid invasion, muscle invasion, lymph node involvement, and extra-thyroidal extension; and procedures, such as surgeries, neck dissection, and radiotherapy treatment. The disease-free survival (DFS) and overall survival (OS) rates were calculated using the Kaplan-Meier method. Results: Recurrences are associated to older age, the presence of metastasis, the initial T stage, radioactive iodine therapy usage, and whether the patient received adequate treatment. Multifocality, lymphovascular space invasion, perithyroidal invasion, muscle invasion, lymph node involvement, and extra-thyroidal extension were observed in 21%, 14%, 17%, 9%, 40%, and 18% of the patients, respectively. The 5-year disease-free survival was 53.3%, and the overall survival was 85.8% at the time of study. Conclusions: In terms of clinicopathological features, the tall cell variety of papillary thyroid cancer has been proven to be aggressive. PTC-TCV has a female sex propensity and is most common in the fifth decade of life. Although the tall call variation has worse features, this does not always imply a poor prognosis. © 2024 Surgical Society of Northern Greece. All rights reserved.