Objectives: The objective of this study was to analyze the difference towards orthodontists’ and laypeople’s perceptions of four smile analysis components in individuals with various vertical skeletal patterns. Material and Methods: Each of the 100 orthodontists, and laypeople aged 26–65 years old were asked to complete an online questionnaire about four smile analysis components in individuals with various vertical skeletal patterns. The questionnaire consists of 36 modified photos according to various smile curves, buccal corridors, gingival displays, and incisor displays in normal, hypodivergent, and hyperdivergent skeletal patterns. Perceptions were assessed using a visual analog scale. Results: Significant differences were found in straight and parallel smile curve, maximum buccal corridor, and gingival display 4 mm components in all vertical skeletal patterns. Additionally, differences were also found in the medium buccal corridor in hypodivergent skeletal pattern, gingival display 2 mm in normal and hypodivergent skeletal patterns. Moreover, significant differences were also observed in the 100% incisor display in normal vertical skeletal pattern, and 50% incisor display in hyperdivergent skeletal pattern Conclusion: Orthodontists and laypeople have similar perceptions toward the most esthetic components (parallel smile curve, minimum buccal corridor, gingival display 0 mm, and incisor display 75%) in all vertical skeletal patterns. © 2024 Published by Scientific Scholar on behalf of APOS Trends in Orthodontics.