Persons with End Stage Renal Disease (ESRD) experience poor quality of life due to poor physical function. After the transplant, his physical fitness did not improve, ultimately creating a vicious cycle of inactivity, increasing the risk of cardiovascular and other causes of death. A 39-year-old man was diagnosed with ESRD and underwent a renal transplant from a living donor. He underwent early post-operative rehabilitation from day one and continued until he was discharged. The study was conducted at Dr. Cipto Mangunkusumo National Hospital. Persons with ESRD showed significant improvement during the rehabilitation program. On the sixth day, he took a 4-meter walk test in 17.58 seconds and made a good impression. He was then discharged and continued remote rehabilitation until day 14. Physical inactivity leads to decreased survival, increased morbidity, and increased mortality. Early rehabilitation for post-renal transplantation may become a potential intervention to improve a person with ESRD’s physical activity and quality of life, especially in Indonesia. © (2023), (Iranian Society for Organ Transplantation). All rights reserved.