This scoping review aims to investigate the impact of Intermittent Hypobaric Hypoxia (IHH) Therapy on the immune expression of Hypoxia-Inducible Factor-1 alpha (HIF-1α) and Vascular Endothelial Growth Factor (VEGF) in the context of osteogenesis of the mandibular bone. Through a systematic literature search of the PubMed, Scopus, and Web of Science databases, this review assessed the evidence linking IHH to increased expression of HIF-1α and VEGF, which play essential roles in osteogenesis and angiogenesis. Several studies showed that IHH exposure significantly increased the expression of HIF-1α and VEGF, which contributed to the stimulation of osteogenesis and angiogenesis in the mandibular bone, as seen from the histological and radiographic parameters improvement. The conclusions of this review support the concept that IHH can facilitate osteogenesis of the mandibular bone through mechanisms involving activation of HIF-1α and increased expression of VEGF. © RJPT All right reserved.