Vaccine is important to defend human against SARS-CoV-2, the coronavirus that cause COVID-19. Recently, several cases of allergic reaction after injection of the mRNA COVID-19 Vaccine had been reported, which has resulted a recommendation to prohibit any individual with a record of a serious or type 1 hypersensitivity reaction to certain of the vaccine constituents. To report the treatment and pathogenesis of injection-induced trigeminal neuralgia and cervical radiculopathy of 25 years old female patient after Covid-19 vaccine. The patient reported pain less than 24 hours on left shoulder, mandibular and periauricular after received an intramuscular Covid-19 vaccine. She was diagnosed with injection-induced trigeminal neuralgia and cervical radiculopathy. Previous clinical diagnosis was adverse vaccine reactions and neuromuscular injuries. Radiograph examination revealed dextroscoliosis. Acetaminophen was given for 4 days and the complaint was diminished on the fifth day. This case emphasizes the importance of taking thorough history especially patient with scoliosis before receiving intramuscular vaccines injection.