Background: The use of pesticides in the agricultural sector often leads to the contamination of foodstuffs by residues, which becomes a source of exposure to the body and causes health problems. Objective: Therefore, this study aims to analyze the health risk of consumption of foodstuffs containing organophosphate residues among farmers in the North Dempo Sub-district of Pagar Alam City, South Sumatera, Indonesia. Method: The study procedures were carried out with a crosssectional method using the Environmental Health Risk Assessment (EHRA). The sample population comprised 117 farmers in the North Dempo Sub-district of Pagar Alam who were selected randomly. Environmental samples comprised 5 red chilies and 5 tomatoes, which were selected purposively. Organophosphate residues were then quantified using Liquid Chromatography Tandem Mass Spectrometry, while body weight was measured with calibrated body scales. Subsequently, activity pattern data were collected through interviews using a questionnaire, followed by analysis with EHRA formulas. Results: The results showed that red chillies contained chlorpyrifos at a concentration of 3,05 mg/kg, while profenofos was found at 0.0731 mg/kg and 0.0118 mg/kg. In the tomato samples, chlorpyrifos was observed at a concentration of 0.4439 mg/kg, while profenofos was present at 0.0112 mg/ kg and 0.2043 mg/kg. The Risk Quotient for consumption of red chilies containing chlorpyrifos was 0.0447, while that for profenofos was 0.2476. The Risk Quotient for consumption of tomato containing chlorpyrifos was 0.0302, while a value of 2.92 was obtained for profenofos. Conclusion: Based on the results, the farmers were at non-carcinogenic health risk due to the consumption of foodstuffs containing profenofos. © 2025, Universitas Negeri Semarang. All rights reserved.