Objective: To explore the occurrence of congenital anomalies identified at Dr. Cipto Mangunkusumo Hospital, a leading tertiary referral center in Indonesia. The findings emphasize the necessity for comprehensive and integrated healthcare services to improve the management and outcomes for affected newborns. Methods: Data were retrospectively analyzed from a one-year period of prenatal screening at Dr. Cipto Mangunkusumo General Hospital, comprising 323 patients. The analysis included variables such as maternal age, date of birth, obstetric history, gestational age, and detected fetal anomalies. Results: Pregnant women aged 30–39 years accounted for the majority of congenital anomaly cases. Most abnormalities were detected during the second trimester (13–28 weeks of gestation). Central nervous system defects were the most common (159 cases), followed by cardiovascular abnormalities (130 cases). In total, 607 anomalies were recorded in 494 patients during the screening period. Conclusion: This research reveals the frequency of congenital anomalies detected over a year at Dr. Cipto Mangunkusumo Hospital. The findings underscore the importance of timely prenatal diagnostics and well-structured perinatal care, particularly in high-level referral hospitals. Strengthening early screening and intervention efforts may enhance health outcomes for both mothers and infants. Copyright (c) 2025 Indonesian Journal of Obstetrics and Gynecology. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.