Background: Assessment of quality of life is needed to assess therapeutic response. There is currently no instrument available for assessing the quality of life of chronic urticaria patients in Indonesia. CU-Q2 oL is a specific questionnaire for chronic urticaria that was first developed in Italian. Validity and reliability tests are important to ensure that the language or term used are appropriate to the local culture and there is no change in the validity and reliability of the questionnaire. Objective: The aim of this study is to develop an Indonesian version of CU-Q2 oL. Methods: The Italian version CU-Q2 oL was translated into Indonesian and underwent cross-cultural adaptation. The translated questionnaire was completed online by 40 chronic urticaria patients of the Dermatovenereology Outpatient Clinic of the Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. Results: Validity test resulted in correlation coefficient values for all questions of 0.467 to 0.856. Reliability test showed a Cronbach’s α coefficient of all questions of 0.923 and the intraclass correlation coefficient (ICC) for all questions was 0.913. Conclusion: This study demonstrates that the Indonesian CU-Q2 oL questionnaire is valid, reliable, and suitable to assess the quality of life of chronic urticaria patients in Indonesia. © 2025, Allergy and Immunology Society of Thailand. All rights reserved.