Background: Breast reconstruction in women with breast cancer has not been thoroughly investigated in Indonesia. A pioneering study is needed to identify the breast reconstruction rate, treatment outcomes, and factors influencing treatment in a smaller population. Methods: The secondary data of 105 women with breast cancer who underwent reconstruction post-breast surgery at several cancer centers in Jakarta were collected retrospectively from 2020 to the first quarter of 2024. We performed Fisher’s exact test, independent t-test, and multiple regression analyses to determine factors influencing the choice of breast reconstruction and surgical outcomes. Results: The breast reconstruction rate at one center after 2 years was 56.8%, and the multicenter trend of breast reconstruction increased by 7.6% after 1 year. Plastic surgeons performed 36.8% of the total breast reconstructions, with DIEP-free flaps being the most performed type of reconstruction. The history of radiotherapy (P=0.03), type of breast surgery (P<0.05), and surgical site of the breast surgery (P<0.05) were significantly associated with the choice of breast reconstruction in women with breast cancer. Moreover, lymph node dissection (P=0.03), the timing of breast reconstruction (P=0.05), and the presence of complications (P=0.002) were significantly associated with the length of ICU stay. Conclusion: The breast reconstruction rate in our study was higher than several centers across Asia (56.8%). However, further investigation is needed to evaluate the outcomes of therapy and factors influencing them. © 2025 Farname Inc.. All rights reserved.