Objective: To assess the learning motivation level in Oral Medicine (OM) among Universitas Indonesia dental students. Material and Methods: This research used an analytic-descriptive study with a cross-sectional design by gathering data directly from total population of Universitas Indonesia dental students. Participants were divided into three groups based on curriculum: G1: pre-clinical who have not had OM, G2: pre-clinical who had taken OM, and G3: clinical years. Data gathering was using Science Motivation Questionnaire II (SMQ-II), which include five motivation components: intrinsic motivation, self-efficacy, self-determination, grade motivation and career motivation. Results: The response rate of this study was 96.6% (743 subjects). The Intraclass Correlation Coefficient of 0.941 indicated good internal consistency. In discriminant validity test, grade motivation and career motivation of pre-clinical groups showed no significant difference. Among three, G3 acquired the highest mean score for highly motivated groups (67.27), followed by G2 (65.89), ended by G1 (62.54). The highest mean score for overall motivation, acquired by G3. Conclusion: Clinical years group have the highest motivation level to learn in Oral Medicine. © 2020, Association of Support to Oral Health Research (APESB). All rights reserved.