Pancreatoblastoma is an exceptionally rare tumor that primarily affects the young population, with even fewer cases reported in adults. The rarity of this disease often leads to underdiagnosis and misdiagnosis, resulting in delayed treatment and a worsened prognosis. We report two cases of pancreatoblastoma, one in a child and one in an adult, to highlight the challenges in reaching a definitive diagnosis prior to surgery despite extensive laboratory and imaging examinations. This is to raise awareness and improve understanding of pancreatoblastoma, facilitating earlier diagnosis and prompt treatment for better patient outcomes. © (2024), (Ministry of Health). All rights reserved.