PEMF is a method that utilizes electric current using a coil that is powered by dynamic electric current, it will cause a dynamic magnetic field in the coil. In the last few decades, it is known that PEMF has the potential to be used as a modality in the treatment of obesity. For this reason, PEMFs have been studied in vitro as their effect in inhibiting the adipogenesis of Mesenchymal Stem Cells (MSC). But the use of PEMF therapy in inhibiting adipogenesis still has many challenges. Understanding of the mechanisms that occur in cells that are exposed to PEMF is also still very slight. This article reviews the studies that investigated in vitro effect of PEMF in inhibiting adipogenesis studies and the underlying mechanism. In the future, it is hoped that this review can be used as a basic reference for in vivo research and clinical trials related to inhibiting adipogenesis using PEMF. © 2023 Puji Sari, Nuzli Fahdia Mazfufah, Umiatin, Dwi Anita Suryandari, Silvia Werdhy Lestari and Luluk Yunaini.