Objective: This study aimed to examine the association between hypertension, hemoglobin level, and nutrition status with quality of life of hemodialysis patients in Indonesia. Method: This study designed was an analytic correlational study of 119 Indonesian hemodialysis patients. Result: The average age was 54.95 years and mean length of hemodialysis of 32.67 months. The mean score for QoL was 62.51, and the mean score of the hemoglobin level was 7.58 g/dl. The results revealed a significant relationship between hypertension and quality of life (p = 0.005). There was no a significant relationship between quality of life and hemoglobin level (p = 0.336) and nutrition status (p = 0.099). Conclusion: Based on the findings of this study, good controlling of hypertension in hemodialysis patients is important to improve the quality of life. © 2019 Elsevier España, S.L.U.