Probiotics are gaining popularity due to their beneficial role in various health issues. A growing body of studies has demonstrated the benefits of Lacticaseibacillus paracasei in supporting gut health, modulating the immune system, lowering cholesterol, and acting as an antimicrobial and antibiofilm agent. This review summarizes several specific strains of L. paracasei, their benefits, and sources of isolates. L. paracasei is widely found in various traditional fermented foods from different countries. L. paracasei is not only used as a starter culture in the dairy and fermented food industry, but it has the potential to treat a variety of health issues at the cellular and molecular levels. It is fascinating to highlight the most recent findings on the features and role of L. paracasei in health issues. © The Author(s) 2026.