In the recent years, Agile methods have been widely-used in large organization to improve their performance. Since these methods initially designed for small projects and co-located teams, organization faces many challenges when implementing them in large-scale. During the past few years, challenges in implementing Large-Scale Agile have become a popular research topic. However, studies exploring the challenges in large scale Agile development along with best practices solutions through secondary studies is still scarce. This study aims to fill this gap by conducting Systematic Literature Review to identify various challenges as well as the proposed practices and solution to deal with them. A total of 12 papers, the results of SLR process, were analysed. This study identified 28 challenges classified in six categories. The biggest challenge arises from communication and collaboration category, which includes challenges related to team coordination, managing autonomous team, uneven team maturity, and distributed team. The solution of each challenge obtained from related studies and best practices. © 2021 IEEE.