Tuberculosis (TB) is still a health problem in Indonesia because its prevalence ranks second in the world after India in 2023. Regional factors, inadequate health facilities, and limited resources (financial, human, and infrastructure) are challenges requiring innovation to help the government control TB. TB eradication efforts need to be made with a comprehensive and effective approach. One method used is to look at the vast territory of Indonesia; therefore, mapping the vulnerability of TB is highly recommended. Using a Geographic Information System is expected to help map the TB vulnerability areas in Indonesia. Given several epidemiological, socio-geographic, and environmental factors influencing TB, the question arises of how to map TB vulnerability areas in Indonesia. This study used a cross-sectional design, secondary data was collected from several sources, and a vulnerability analysis was performed by considering several socio-environmental epidemiological variables. Furthermore, after the analysis, the TB area vulnerability category would be obtained along with a map of TB vulnerability areas in Indonesia according to regional and district analysis units. This study produces a TB susceptibility index and map for Sumatra, Java-Bali, and other regions in Indonesia. © 2024, Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal).