Objective: This study aimed to explore the perceptions of STEMI patients after Percutaneous primary intervention regarding their readiness to conduct and maintain self-care. Method: The study used a qualitative design. Fifteen STEMI patients after Percutaneous primary intervention and nine partners of them were interviewed in the inpatient unit at the main referral government cardiac center in Indonesia. Data were analyzed using content analysis. Results: The results showed there is an inability to recognize and manage ischemic symptoms immediately. Patients had physical problems following primary PCI such as cough, chest tightness, chest pain, bloating and get tired easily—psychological problems experienced by the patient and his partner at the acute and recovery phase. Conclusion: The findings provide for health care professionals in developing self-care ability among STEMI patients at first attack following primary PCI by considering the influenced factors © 2019