Objective: This study aimed to determine the influence of “Sehati” Health Education on physical and psychological adaptation of pre-eclamptic postpartum women. Method: We used a quasi-experimental pre- and post-test with control group study design. We recruited 60 postpartum mothers in Banyumas and Purbalingga, Indonesia, selected with consecutive sampling. “Sehati” health education and home visits were provided for the intervention group. Data were collected using the Postpartum Specific Anxiety Scale (PSAS) and Multidimensional Scale of Perceived Social Support (MSPSS) questionnaires. Results: There were significant differences in physical and psychological adaptation before and after the health education (p = 0.039; p = 0.007, respectively) in the intervention group. There were also significant physiological and psychological adaptation differences between groups after the intervention (p = 0.018; p = 0.004). The results of logistic regression analysis demonstrated that “Sehati” health education had a dominant effect on postpartum physiological adaptation with an OR score: 5.114 (95% CI: 1.498–17.465) and on postpartum psychological adaptation with an OR score: 6.671 (95% CI: 1.890–19.043). Conclusion: “Sehati” health education influenced the physiological and psychological adaptability of pre-eclamptic postpartum women. It could be provided as a nursing intervention to assist postpartum women with pre-eclampsia. © 2019