Objective: This study purposed to determine the relationship of informational support from family with self-efficacy of tuberculosis clients. Method: It applied cross sectional design to 99 tuberculosis clients as purposive samples at one Public Health Center in South Jakarta. The result showed that there was a relationship between informational support and self-efficacy (p value 0.002, α 0.05). Results: The TBC clients with less family support were at risk of 4.047 times of low self-efficacy compared to clients with good family supports (95% CI OR: 1.721; 9.519). Conclusion: The study concluded that informational support is important for tuberculosis treatment. This study recommends empowering family in providing informational support to increase the self-efficacy among tuberculosis clients. © 2019