Cigarette smoking is a well-established risk factor for periodontitis. The high prevalence of smoking in Asia therefore could affect the severity of periodontal disease and the outcome of periodontal therapy in Asia. This systematic review and meta-analysis aims to determine the clinical periodontal parameter of smokers with periodontitis in Asia following periodontal therapy. The protocol has been registered to PROSPERO database (CRD42020201607). Literature search followed the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses) guideline through electronic databases (PubMed, Scopus, EBSCO). A total of 868 studies were identified from the electronic databases. Title and abstract were screened from the 415 remaining studies, and 357 irrelevant studies were excluded. Full text from the remaining 58 studies were assessed for potential eligibility, and only 19 studies met the inclusion criteria. Statistical Analysis used: Meta-analysis using random-effect model was performed using Exploratory Software for Confidence Intervals (ESCI) software. Meta-analysis results for changes in periodontal pocket depth (PPD) demonstrated a reduction in periodontal pocket depth in both smokers and non-smokers group, with a mean difference of - 0.83 mm (95% CI: -1.23 mm; -0.43 mm) and a mean difference of -1.13 mm (95% CI: -1.53 mm; - 0.73 mm), respectively. Meta-analysis results for changes in clinical attachment level (CAL) demonstrated a gain in clinical attachment level (CAL) in both smokers and non-smokers group, with a mean difference of -0.98 mm (95% CI: -1.40 mm; -0.56 mm) and a mean difference of -0.97 mm (95% CI: -1.57 mm; -0.38 mm), respectively. Smokers with periodontitis in Asia shows less reduction in periodontal pocket depth, indicating that smoking has a negative effect on the outcome of periodontal therapy. © 2022. Journal of International Dental and Medical Research. All Rights Reserved.