The upstream oil and gas (O&G) industry faces persistent challenges, including volatile oil prices, declining reserves, and the increasing prominence of renewable energy sources. In response, the Indonesian government has set an ambitious target to increase national O&G production by 70% by 2030. This goal requires upstream O&G producers to adopt innovative approaches that enhance performance and resilience. This study emphasizes organizational agility as a critical capability for organizations in VUCA environments to remain resilient and competitive. This study examines the influence of relevant agility enablers on Indonesian upstream O&G, ensuring that no critical factors are overlooked in the implementation of agility. The human–technology–organization (HTO) framework was used to conceptualize and examine its role in supporting organizational agility. Data were collected from 103 managerial-level respondents representing 27 producer companies representing more than 75% of Indonesia’s overall O&G production. PLS-SEM was employed to examine whether relationships existed among predictor variables and organizational agility. The results highlight HTO, leadership, and innovation capacity as significant enablers of organizational agility. This study contributes theoretically and practically by integrating the HTO framework into the agility discourse and offering a comprehensive view of agility enablers that foster transformation, resilience, and sustainability of Indonesia’s upstream O&G sector. © 2025 by the authors.