Objective: To determine the effectiveness of Brief Intervention (BI) on alcohol consumption in People Living with HIV (PLHIV). Methodology: A literature search was conducted across six databases (ScienceDirect, ProQuest, Scopus, Sage Journals, EMBASE, and EBSCOHost) using the keywords Brief intervention, alcohol, alcohol consumption, HIV, PLWH. Inclusion criteria were studies published between 2013-2023, RCT, adult population, English, open access, full-text, and final stage. Six RCTs (n=1,974) were included. Results: All included studies consistently found that BI led to a significant reduction in alcohol consumption. Specifically, studies reported a decrease in mean drinks per day, with reductions ranging from 15% to 30% at follow-up. Furthermore, the majority of studies demonstrated an improvement in antiretroviral therapy adherence in groups receiving BI alone or combined with technology. Conclusion: BI is an effective intervention with a substantial magnitude of effect for reducing alcohol consumption and enhancing ART adherence among PL-HIV. © 2026, Pakistan Medical Association. All rights reserved.