Background: Left ventricular (LV) dysfunction is a common and serious complication from cancer treatment. One of the common regimens that can cause cardiotoxicity is anthracycline, and anthracycline-induced cardiotoxicity may manifest after several years. Case Summary: A 32-year-old woman presented with heart failure syndrome late after chemotherapy administration for breast cancer therapy. Several months after chemotherapy completion, patient presented with overt LV dysfunction. The guideline-directed medical treatment was initiated. Patient demonstrated gradual recovery and progressive improvement of myocardial systolic performance with LV thrombus resolution after 5-month evaluation. Discussion: The recognition of cancer therapy–related cardiac dysfunction (CTRCD) is important since early detection and treatment with heart failure treatment provide a good functional recovery and long-term prognosis. The clinical application of longitudinal strain and myocardial work echocardiography in CTRCD cases for therapeutic response tracking and prognostication purposes is recommended. Take-Home Message: Long-term postchemotherapy echocardiography evaluation especially in high-risk CTRCD criteria is of utmost importance due to the possibility of late-onset CTRCD. © 2025 The Authors