The trend of knowledge-based economy gives awareness that university governance must transform from research university to entrepreneurial university. This study aims to analyze how Bandung Institute of Technology (ITB), as one of the Higher Education Institution (HEI) in Indonesia, has a strategic plan to become an entrepreneurial university (EU). The Entrepreneurial University is defined as a university that uses natural incubators which provide a support structure for lecturers and students to start new, intellectual and commercial ventures. The method of this research is qualitative approach through in-depth interview and studying literature of secondary data. The results of this study indicate that the ITB's commitment and vision are crucial to building an entrepreneurial culture or atmosphere within the framework of the university's tridarma. In addition, the challenges that arise are at the macro level, where government regulations related to state-autonomous higher education are policies that must be adapted to the needs of ITB towards the EU. Copyright © 2019 by authors, all rights reserved.