Background: Obesity is an accumulation of excessive fat tissue that can affect health. Acupuncture has a positive effect on leptin, ghrelin, insulin resistance, glucose metabolism, lipids, serum immunoglobulin levels, and decreased appetite. Laser as an acupuncture modality can be a good option because it is easy to apply, noninvasive, and painless. Laser acupuncture works using a laser pulse to stimulate acupuncture points with a therapeutic effect similar to needle acupuncture. Case: A 19-year-old woman came to the acupuncture clinic of Cipto Mangunkusumo Hospital (Jakarta, Indonesia) wanting to lose weight and slim down. Acupuncture was done at the following points CV12, ST25, SP15, ST40, ST36, and SP6 with a laser needle multilead continuous wave 4 J for each point with power density 40 mW for 7 minutes. Acupuncture was done with a laser pen RJ-Laser continuous wave 0.5 J for each hunger point with power density 50 mW for 25 seconds, therapy was performed 3 times a week for 2 months. Results: Decrease in body weight and a decrease in abdominal circumference were noted after 24 sessions. The highest peak of weight loss at the 18th session was 11.5 cm in the umbilicus circumference, above the umbilicus by 6.5 cm, below the umbilicus by 9 cm, then stable with the final result of a decrease in the umbilicus circumference of 10 cm, above the umbilicus by 4 cm, and under the umbilicus by 5 cm. Decrease in random blood sugar was noted from 122 to 100 mg/dL. Conclusion: A combination of laser needle multilead and laser pen had good results in this case and may be useful for weight loss and a decrease in abdominal circumference in obese patients. Copyright © 2022, Mary Ann Liebert, Inc.