Toxoplasma gondii, which is an obligate intracellular protozoan, and its primer infection during pregnancy can cause several problems. This study presents a case report of a woman who delivered a baby with multi-organ failure and was diagnosed with congenital tox-oplasmosis. During the gestation period, there was no history of febrile, enlargement of lymph nodes, or common cold symptoms, but there was a history of miscarriage. The serology test of anti-Toxoplasma im-munoglobulin (Ig)G and IgM were reactive. The IgG avidity test was 90%, and positive SAG2. The sequencing and analysis of polymerase chain reaction product assumed to have the Type I T. gondii, which must be confirmed using other loci apart from SAG2. This case report aims to raise awareness of the risk of congenital toxoplasmosis in asymptomatic mothers with a history of miscarriage. Routine and serial screening for the disease is recommended in high-risk pregnant women to prevent congenital transmission. © 2023 by Türkiye Klinikleri.