Background: The COVID-19 pandemic, spread rapidly to various countries and caused the prevalence, mortality and case fatality rates to continue to increase significantly. Mortality of COVID-19 continue to increase in Indonesia especially in Depok City, and little evidence is available indicating only the age and sex of the disease. Objective: To study the relationship between sex and age in patients dying among COVID-19 positive cases. Methods: This study used a case control design. The study population was COVID-19 patients recorded at the Depok Covid-19 Information Center (PICODEP) with a sample of 87 patients. The ratio of cases and controls was 1:4. So the total sample is 435 patients. The data collected is in the form of secondary data, namely surveillance data for confirmed Covid-19 patients in Depok City for the period June-September 2021. Researchers used the chi square test to see the relationship between age and sex to COVID-19 mortality. Results: In the sex variable, a p-value of 0.046 was obtained, meaning that p < (0.05) means that there is a relationship between male sex and the incidence of death in COVID-19 patients. From the analysis, the OR value = 1.663, which indicates that male COVID-19 patients are 1.663 times more likely to experience death in COVID-19 patients than women. Furthermore, the age variable shows that there is a relationship between the elderly age group and the incidence of death in COVID-19 patients with a p-value of 0.007 with the elderly age group having a 14.4 times higher risk of experiencing death in COVID-19 Covid-19 patients compared to the under-five age group (OR: 14,400; 95% CI: 1,640 – 126,443 p value=0.007). Conclusion: There is a relationship between age and sex on COVID-19 mortality. © 2023 MPPKI. All rights reserved.