Overweight (Obesity) and administration of ovarian stimulation regimen have a negative impact on endometrial receptivity during implantation. It is known that the receptive condition of the endometrium during the embryo implantation reception period is characterized by the expression of various receptivity markers, one of which is E-Cadherin. The purpose of this study was to analyze and compare the level of E-Cadherin expression in the endometrium of normal weight female rats with a group of stimulated normal weight rats, a group of overweight rats and a group of stimulated overweight rats. overweight, obesity and normal weight in the stimulated and unstimulated groups. Methods, 3-month-old female Wistar rats with a normal body weight of around 200grams and overweight rats (given a high-calorie fat diet) for 2-3months), an average body weight of 275grams. Normal weight rats were stimulated once with recombinant FSH (Gonal F) intraperitoneally at a dose of 15–20IU and overweight rats were injected with a dose of 20-25 IU FSH in the diestrus phase. 48 hours after injection (estrus phase), the rats were mated with male rats (Vaginal plug). Endometrium sampling was performed serially on days 3, 4, and 5 after mating. E-Cadherin expression was examined using immunohistochemical staining (IHK). Using the IHK score calculation formula = (% positive high cell contribution x 4) + (% positive cell contribution x 3) + (% positive low cell contribution x 2) + (% negative cell contribution 1), Results, E-Cadherin expression in the endometrium of rats in the normal weight group did not show a significant difference in expression levels compared to the stimulated normal weight rat group (P = 0.07). When compared with the group of overweight mice that were not stimulated, there was a significant increase in expression levels (P = 0.02). Furthermore, with the expression of E-Cadherin in the group of overweight mice that were stimulated, there was a significant increase (P = 0.01). Conclusion, E-Cadherin expression increased significantly in overweight female mice, both stimulated and unstimulated, compared with normal weight mice. © RJPT All right reserved.