Introduction: Treating maxillofacial fractures in Indonesia is costly, largely due to the reliance on imported miniplates and screws. This study evaluates the bone healing properties and biocompatibility of a locally manufactured 1.5 system titanium miniplate and screw implant, designed for internal fixation of maxillofacial fractures, as an alternative to imported options. Methods: Thirty Oryctolagus cuniculus species of rabbits were divided into two groups: locally made implants and control. A standardized osteotomy was performed on the right zygomatic arch of each rabbit, followed by internal fixation with 4-hole 1.5-system titanium miniplates and 5mm screws. Postoperative assessments included histopathological and radiographic evaluations on days 5, 28, and 56. ImageJ software was used to measure bone healing and inflammation for bone and muscle density, as well as peri-implant tissue responses. Results: Histopathological analysis revealed comparable bone healing in both the locally made and control groups, with inflammation peaking on day 5 and lamellar bone formation observed by week 8. The locally made implant group exhibited a higher percentage of lamellar bone formation (65.3% ± 3.7) compared to the control (52.2% ± 6.5, p = 0.028). Both groups showed no significant differences in metal debris, with no signs of foreign body reactions. Radio-graphic evaluation confirmed similar bone healing progress between groups, with inflammatory responses subsiding by day 28 based on muscle density measurements. Conclusions: The locally manufactured 1.5 system titanium miniplates and screws demonstrate bone healing properties and biocompatibility comparable to imported systems, offering a cost-effective alternative for maxillofacial fracture management in Indonesia. © 2025 Universiti Putra Malaysia Press. All rights reserved.