Transmission of toxoplasmosis is influenced by interacting disease agents, hosts and environmental conditions. Nutritional status is a host factor that cannot be ignored. Some studies suggest that high body mass index has a strong association with Toxoplasmosis. This study aims to analyze anti-toxoplasmosis IgM and IgG titers based on nutritional status in patients with malignancies who receive chemotherapy at the Lampung Provincial General Hospital, Indonesia. The design of this study was cross-sectional. The population of this study were malignancy patients who received chemotherapy with or without symptoms of infection at Lampung Provincial Hospital. Blood samples were examined for Toxoplasmosis serology to measure IgG and IgM titers. Examination with CMIA technique. Data analysis was done descriptively followed by Anova or Kruskal Wallis test. The results of this study showed that there were no differences in mean age, IgM and IgG titers in the three nutritional status groups. © The Authors, published by EDP Sciences, 2023.