Inadequate xeros is treatment may result in complications. This study aimed to comparing the efficacy and side effects of moisturizing cream containing 10% urea and 10% lanolin in petrolatum for the treatment of xerosis in elderly.A randomized, double blind clinical trial was conducted in 35 elderly from a nursing home in Jakarta. Evaluation of skin capacitance (SC),specified symptoms sum score(SSRC), and pruritic degree were measured at baseline, week-2 and -4 after the start of therapy. Followinga 2-week preconditionperiod, eachsubjectreceivedarandommoisturizer for each limb, to be applied twice daily.Thepercentageof SC increaseatweek-4 was significantly higher in limb receiving cream containing 10%urea than 10% lanolin/petrolatum (64.54% vs. 58.98%; p=0.036). Thepercentage of SSRC decreaseatweek-4 did not differ between groups (100%; p=0.089). Pruritus was equally improved in both groups at week-2, and completely diminishedatweek-4. Overall, the most frequent side effect was sticky feel, more common, but not statistically significant, in 10% lanolin/petrolatum group.Afterfourweek application moisturizer containing 10% urea gave higher percentage of SC increase than 10% lanolin/petrolatum in the xerotic limbs of the elderly. Sticky feeling was more frequently found in 10% lanolin/petrolatum group, butstatisticallynotsignificant. Published by Oriental Scientific Publishing Company © 2020