The usage of cloud computing is needed for educational sector, especially in universities to ease all of administration and learning access to everyone. So that, the development infrastructure cloud computing need to concern the aim of the university. Infrastructure as a Service (IaaS) in cloud computing has problems, like resource, security, and finance. This study follows Kitchenham protocol to explore the challenges in the cloud computing as a infrastructure service for education field literature systematically, then reviewed their techniques which can use to all of university in Indonesia. This study recommends that the management of IaaS should be considered well to get result development of cloud computing optimally. Copyright © 2021 by SCITEPRESS – Science and Technology Publications, Lda. All rights reserved.