Background: Honey through its antimicrobial properties has an effect on wound healing. We would like to report the clinical change of wound dehiscence after cesarean section using honey dressing before primary re-closure. Case illustration: A-29-year-old woman came with an open abdominal wound with smelly pus 7 day after cesarean section. We used honey “Madu Nusantara” for the wound dressing until the granulation tissue grew before we performed re-closure. We performed primary re-closure 9 days after wound care. Discussion: Wound healing as a complex process involves immunological mediators to bring back the cellular integrity from the damaged tissue. An alternative natural compound, honey, is known to have benefits in wound healing through the action of neutrophils to eradicate the reactive oxygen species. Honey is believed to reduce the wound size, fasten the healing time, decrease the extent of infection, dehiscence, and pain compared with placebo. Primary re-closure had demonstrated superiority over secondary intention healing. Conclusion: In abdominal wound dehiscence after cesarean section, honey can be an alternative method for dressings in district area of Indonesia due to effectivity and efficacy. Primary re-closure is useful to shorten the healing time. © The Author(s). 2023 Open Access.