As an emerging country, Indonesia is still in the process of imple-menting prophylaxis as a standard of care for managing hemophilia with limited real-world evidence in Indonesian patients. This case series details the effects of tertiary prophylaxis with an intermediate dose of factor VIII concentrate on bleeding outcomes and musculoskeletal function in three Indonesian adolescents suffering from severe haemophilia A and associated arthropathy. [Paediatr Indones. 2025;65:268-72; DOI: https://doi.org/10.14238/pi65.3.2025.268-72 ]. © 2025, Indonesian Pediatric Society Publishing House. All rights reserved.